Mass Spectrometer (Exploris 480)

1.1.

Køber

Officielt navn : Danmarks Tekniske Universitet - DTU

E-mail : mardau@dtu.dk

Køberens retlige status : Offentligretligt organ

Den ordregivende myndigheds aktivitet : Uddannelse

2.1.

Procedure

Titel : Mass Spectrometer (Exploris 480)

Beskrivelse : DTU Bioengineering is looking to acquire a new mass spectrometer and two LC systems to expand their capacity for proteomic samples in the field of spatial proteomics all the way down to single-cell level. The instruments will be used for running large-scale spatial proteomics experiments and will be incorporated into the DTU Proteomics Core. The DTU Proteomics Core at DTU Bioengineering houses five Orbitrap mass spectrometers. With the ambition of expanding in the field of spatial proteomics, the facility has a need to increase their current instrument capacity. Currently the most used instrument is the Orbitrap Exploris 480 instrument, which can’t keep up with the increasing demands. It is therefore vital that the DTU Proteomics Core obtains a duplicate setup, to expand their resources to two Orbitrap Exploris 480s and two matching LC systems. The duplicate setup is specifically needed as expansion into the field of spatial proteomics will result in larger sample sets. This will block the instrument for other smaller projects for weeks to months. The duplicate setup will therefore provide capacity and flexibility of the exact same analysis on either of the two instruments. The DTU Proteomics Core needs the mass spectrometer to fulfil all the following criteria: - Robust instrumentation - Resolving power in the low m/z range required for running multiplexed analysis with TMT-labelling with 18-plex and 35-plex methods - High resolution settings of 120,000 and 240,000 for single-cell analysis - Orthogonal separation for low-input samples and samples with matrix interference

Identifikator for proceduren : 0bc715d4-a2e7-443c-8cd5-2e4ac0911189

Intern ID : 9262

Udbudsprocedure : Udbud med forhandling uden forudgående offentliggørelse

2.1.1.

Formål

Kontraktens hovedformål : Varer

Primær klassifikation ( cpv ): 38430000 Apparater til fysisk eller kemisk analyse

Supplerende klassifikation ( cpv ): 73120000 Eksperimentel udvikling

2.1.2.

Udførelsessted

By : Kgs. Lyngby

Postnummer : 2800

Landsdel (NUTS) : Københavns omegn ( DK012 )

Land : Danmark

2.1.4.

Generelle oplysninger

Retsgrundlag :

Direktiv 2014/24/EU

5.1.

Delkontrakt : LOT-0000

Titel : Mass Spectrometer (Exploris 480)

Beskrivelse : DTU Bioengineering is looking to acquire a new mass spectrometer and two LC systems to expand their capacity for proteomic samples in the field of spatial proteomics all the way down to single-cell level. The instruments will be used for running large-scale spatial proteomics experiments and will be incorporated into the DTU Proteomics Core. The DTU Proteomics Core at DTU Bioengineering houses five Orbitrap mass spectrometers. With the ambition of expanding in the field of spatial proteomics, the facility has a need to increase their current instrument capacity. Currently the most used instrument is the Orbitrap Exploris 480 instrument, which can’t keep up with the increasing demands. It is therefore vital that the DTU Proteomics Core obtains a duplicate setup, to expand their resources to two Orbitrap Exploris 480s and two matching LC systems. The duplicate setup is specifically needed as expansion into the field of spatial proteomics will result in larger sample sets. This will block the instrument for other smaller projects for weeks to months. The duplicate setup will therefore provide capacity and flexibility of the exact same analysis on either of the two instruments. The DTU Proteomics Core needs the mass spectrometer to fulfil all the following criteria: - Robust instrumentation - Resolving power in the low m/z range required for running multiplexed analysis with TMT-labelling with 18-plex and 35-plex methods - High resolution settings of 120,000 and 240,000 for single-cell analysis - Orthogonal separation for low-input samples and samples with matrix interference

Intern ID : 9262

5.1.1.

Formål

Kontraktens hovedformål : Varer

Primær klassifikation ( cpv ): 38430000 Apparater til fysisk eller kemisk analyse

Supplerende klassifikation ( cpv ): 73120000 Eksperimentel udvikling

5.1.2.

Udførelsessted

By : Kgs. Lyngby

Postnummer : 2800

Landsdel (NUTS) : Københavns omegn ( DK012 )

Land : Danmark

5.1.3.

Anslået varighed

Startdato : 01/10/2024

Varigheds slutdato : 30/09/2025

5.1.6.

Generelle oplysninger

Indkøbsprojekt, der ikke finansieres med EU-midler

Udbuddet er omfattet af aftalen om offentlige udbud (GPA) : ja

5.1.10.

Tildelingskriterier

Kriterium :

Type : Pris

Navn : Price

Beskrivelse : Price in suppliers quote is crucial.

Vægtning (procentdel, præcis) : 100

5.1.12.

Udbudsvilkår

Oplysninger om klagefrister : Complaint that the Contracting Authority, contrary to the Public Procurement Act, has concluded a contract without prior publication of a contract notice in the European Union Official Journal must be submitted no later than 30 calendar days from the date after a contract award notice has been published by the Contracting Authority in the European Union Official Journal and that contract award notice includes the grounds for the decision to award the contract directly, cf. lov om Klagenævnet for Udbud (Complaints Board for Tenders) § 7, section 3.

5.1.15.

Teknikker

Rammeaftale : Ingen rammeaftale

Oplysninger om det dynamiske indkøbssystem : Intet dynamisk indkøbssystem

5.1.16.

Yderligere oplysninger, mægling og gennemgang

Organisation med ansvar for klager : Klagenævnet for Udbud

Organisation, der leverer oplysninger om den generelle lovgivningsramme angånde skatter på det sted, hvor kontrakten skal udføres : Konkurrence- og Forbrugerstyrelsen

Organisation, der leverer supplerende oplysninger om udbudsproceduren : Danmarks Tekniske Universitet - DTU

Organisation, der sikrer adgang til udbudsdokumenterne offline : Danmarks Tekniske Universitet - DTU

Organisation, hvis budget anvendes til at betale for kontrakten : Danmarks Tekniske Universitet - DTU

Organisation, der udfører betalingen : Danmarks Tekniske Universitet - DTU

Organisation, der underskriver kontrakten : Danmarks Tekniske Universitet - DTU

TED eSender : Mercell Holding ASA

Værdien af alle kontrakter tildelt i denne bekendtgørelse : 3 832 726,10 DKK

Direkte tildeling :

Begrundelse for direkte tildeling : Kontrakten kan kun tildeles af en bestemt økonomisk aktør på grund af manglende konkurrence af tekniske årsager

Anden begrundelse : The Orbitrap Exploris 480 mass spectrometer is produced by Thermo Fisher Scientific. This mass spectrometer has a high-field Orbitrap analyser with resolving power from 7,500 up o 480,000 FWHM at m/z 200. Coupled to the Vanquish Neo UHPLC system, that can operate at low-flow from 0.001-100 uL/min at max. 1500 bar, this instrumentation will enable high-sensitivity LCMS workflows for low-input samples. The acquisition will duplicate the already existing Orbitrap Exploris 480 sys-tem at DTU Bioengineering, and will therefore serve to increase our throughput and flexibility in the field of proteomics, with a special focus on spatial proteomics. The Orbitrap Exploris 480 fulfil the above mentioned criteria by having a resolving injection filter and bent flatapole to improve robustness. It has a segmented quadrupole mass filter with rod-switching capabilities for increased robustness in front of a C-trap with a hyperbolic surface, which provide excellent peak shape and transmission with a minimum resolution of 0.4 FWHM. The high-field Orbitrap Mass Analyzer with enhanced FT transient processing results in a resolving power from 7,500 up to 480,000 FWHM at m/z 200 and isotopic fidelity, m/z range of 40-6000, and with up to 40 Hz acquisi-tion speed. The high resolution of the Orbitrap Mass Analyzer at low m/z is required for multiplexing workflows with 18-plex and 35-plex TMT-labelling. The instrument has high resolution settings of 120,000 and 240,000 necessary for single-cell proteomics applications. The Orbitrap Exploris 480 is also fitted with a FAIMS Pro Duo interface that provides an orthogonal mode of separation for complex samples or samples with high matrix interference. The FAIMS Pro Duo is crucial for low input samples such as single-cell. The DTU Proteomics Core needs the LC instrumentation to fulfil all the following criteria: - Support flowrates from nano-flow to micro-flow in the same instrument - Robust performance for large sample sets - High retention time precision at both short and long gradients - Short overhead time for to increase throughput for large sample sets The Vanquish Neo UHPLC fulfil these criteria as an all-in-one nano-, capillary-, and micro-flow LC for high-sensitivity LCMS workflows supporting direct and trap-and-elute injections for low-flow applications from 0.001-100 uL/min at max. 1500 bar. The next generation SmartInject technology minimizes column pressure shock resulting in improved retention time precision, longer column lifetime and stable electrospray ionization response. The instrument has fast sample loading and column equilibration modes with the pump operating at constant elevated pressure. This reduces overhead time and boosts throughput. Thereby, analysis time of large projects can be cut from months to weeks with short gradients and short overhead time. The Vanquish Neo systems are the only LC system on the market which such versatile capabilities and long-term robustness. The acquisition to upgrade the capacity for spatial proteomics will be a refurbished Orbitrap Explo-ris 480 with FAIMS Pro Duo interface working as a duplicate to the facility’s current Orbitrap Explo-ris 480. Two Vanquish Neos will be acquired for running together with the two Orbitrap Exploris 480s for increased sample throughput. The acquisition will also include trade-in of two mass spec-trometers (Q-Exactive and Orbitrap Fusion Tribrid) from the DTU Proteomics Core to the vendor. The value of the trade-in is included in the contract value. It is crucial for the DTU Proteomics core to get an improvement in their current capacity for low-input samples, while at the same time having a flexible and efficient setup with some redundancy. These requirements can only be met by acquiring another Orbitrap Exploris 480 to supplement the current Orbitrap Exploris 480 for a dual setup. The contract is awarded to Thermo Electron A/S (a part of Thermo Fisher Scientific) as they are the only providers of the Orbitrap Exploris 480 and Vanquish Neo systems. A market survey was conducted to explore all possible options for acquiring a mass spectrometer and LC systems that fit the criteria. The Orbitrap Mass Analyzer is needed for running samples with TMT multiplexing as high resolution at low m/z is needed for 18-plex and 35-plex panels. The resolution of 120,000 and 240,000 needed for single-cell proteomics is also only available with Orbitrap analysers. Mass spectrometers with other mass analysers would therefore not fit our criteria. The only producent of instruments with Orbitrap analysers is Thermo Fisher Scientific. The Vanquish Neo systems is the only LC system on the market with the versatile capabilities and longterm robustness to meet the criteria. The only producer of Vanquish Neo is Thermo Fisher Scientific. As there is lack of competition due to technical reasons, cf. § 80, subsection 3, no. 2 in the Danish Public Procurement Law, the contract is awarded to Thermo Electron A/S.

6.1.

Resultat delkontrakt-ID : LOT-0000

6.1.2.

Oplysninger om vinderne

Vinder :

Officielt navn : Thermo Electron A/S

Tilbud :

Tilbud – Identifikator : 373768

ID for delkontrakt eller gruppe af delkontrakter : LOT-0000

Kontraktoplysninger:

Identifikator for kontrakten : Mass Spectrometer (Exploris 480)

Titel : Contract regarding purchase of a Orbitrap Exploris 480 and Vanquish Neo

Datoen for udvælgelsen af det vindende tilbud : 06/09/2024

Kontrakten tildeles som led i en rammeaftale : nej

Organisation, der underskriver kontrakten : Danmarks Tekniske Universitet - DTU

8.1.

ORG-0001

Officielt navn : Danmarks Tekniske Universitet - DTU

Registreringsnummer : 30060946

Postadresse : Anker Engelunds Vej 1

By : Kgs. Lyngby

Postnummer : 2800

Landsdel (NUTS) : Københavns omegn ( DK012 )

Land : Danmark

Enhed : Marianne Dauding

E-mail : mardau@dtu.dk

Telefon : +45 33344398

Internetadresse : https://www.dtu.dk/

Køberprofil : https://eu.eu-supply.com/ctm/company/companyinformation/index/165863

Denne organisations roller :

Køber

Organisation, der leverer supplerende oplysninger om udbudsproceduren

Organisation, der sikrer adgang til udbudsdokumenterne offline

Organisation, der underskriver kontrakten

Organisation, hvis budget anvendes til at betale for kontrakten

Organisation, der udfører betalingen

8.1.

ORG-0002

Officielt navn : Klagenævnet for Udbud

Postadresse : Nævnenes hus, Toldboden 2

By : Viborg

Postnummer : 8800

Landsdel (NUTS) : Østjylland ( DK042 )

Land : Danmark

E-mail : klfu@erst.dk

Telefon : +45 35291000

Denne organisations roller :

Organisation med ansvar for klager

8.1.

ORG-0003

Officielt navn : Konkurrence- og Forbrugerstyrelsen

Postadresse : Carl Jacobsens Vej 35

By : Valby

Postnummer : 2500

Landsdel (NUTS) : Københavns omegn ( DK012 )

Land : Danmark

E-mail : kfst@kfst.dk

Telefon : +45 41715000

Denne organisations roller :

Organisation, der leverer oplysninger om den generelle lovgivningsramme angånde skatter på det sted, hvor kontrakten skal udføres

8.1.

ORG-0004

Officielt navn : Thermo Electron A/S

Registreringsnummer : 28314388

By : Allerød

Postnummer : 3450

Landsdel (NUTS) : Københavns omegn ( DK012 )

Land : Danmark

E-mail : peter.milland@thermofisher.com

Telefon : +4570236260

Denne organisations roller :

Tilbudsgiver

Vinder af disse delkontrakter : LOT-0000

8.1.

ORG-0005

Officielt navn : Mercell Holding ASA

Registreringsnummer : 980921565

Postadresse : Askekroken 11

By : Oslo

Postnummer : 0277

Landsdel (NUTS) : Oslo ( NO081 )

Land : Norge

Enhed : eSender

E-mail : publication@mercell.com

Telefon : +47 21018800

Fax : +47 21018801

Internetadresse : http://mercell.com/

Denne organisations roller :

TED eSender

11.1.

Oplysninger om bekendtgørelsen

Bekendtgørelsens ID : db0b6c34-d8cc-4526-88e7-66a559f5a2f7 - 01

Formulartype : Forudgående underretning om direkte tildeling

Bekendtgørelsestype : Bekendtgørelse med henblik på frivillig forudgående gennemsigtighed

Bekendtgørelsesundertype : 25

Afsendelsesdato for bekendtgørelsen : 10/09/2024 09:28:09 (UTC)

Dato for afsendelse af bekendtgørelsen (eSender) : 10/09/2024 10:00:38 (UTC)

Bekendtgørelsens officielle sprog : dansk

11.2.

Oplysninger om offentliggørelsen

Bekendtgørelsesnummer : 546514-2024

EUT-S-nummer : 177/2024

Offentliggørelsesdato : 11/09/2024

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Mass Spectrometer (Exploris 480)

Danmarks Tekniske Universitet - DTU

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